De-e scalation of antibiotic

prophylaxis in

urological procedures

As urologists, we know the importance of perioperative antibiotic prophylaxis, and the DEEP-Uro Study seeks to enhance our understanding in this area. With limited evidence available the optimum use of antibiotic prophylaxis remains unknown. In view of the growing antimicrobial resistance crisis urgent action in contributions to tackle the issue are needed. We're committed to conducting a comprehensive study, and we need your expertise.

  1. Study Initiation

    Anticipated start date for the DEEP-Uro study. Duration: 8 months.

Center Information

The DEEP-URO study, focused on optimizing antibiotic prophylaxis in urological procedures, is supported by the EAU Research Foundation (EAU RF). This collaboration highlights the foundation's commitment to addressing critical healthcare challenges, such as antimicrobial resistance (AMR), through high-quality research and innovative projects. The EAU RF provides essential resources, infrastructure, and guidance to ensure the success of studies like DEEP-URO.

For more information about the EAU Research Foundation's objectives and ongoing projects, visit their current research projects page.

EAU Research FoundationCurrent research projects

Frequently asked questions

Participant Information

DEEP URO Study

What will DEEP-URO do?

DEEP-URO will identify the optimal lowest antibiotic exposure for prophylactic use in urological procedures. Multiple studies will be conducted, starting with five index procedures: radical prostatectomy, radical cystectomy, radical nephrectomy, transurethral resection of bladder tumors, and transurethral resection of prostate.

Where do we start?

The first index procedure will be robot-assisted or laparoscopic radical prostatectomy (RA/LP). Study-specific training will be provided to participating teams.

Prostate cancer information

Prostate cancer is the most common cancer among males. One treatment option is surgery to remove the prostate, which can be done using minimally invasive techniques like robotic-assisted or laparoscopic surgery.

While strict infection control measures are used, there is uncertainty about whether giving antibiotics before surgery (antibiotic prophylaxis) helps prevent post-surgical infections. Unnecessary antibiotic use can have side effects and contribute to antibiotic resistance.

Previous research shows about 5% of patients develop infections after minimally invasive prostate surgery, regardless of whether antibiotic prophylaxis is used. However, no study has specifically examined the risks and benefits of antibiotic prophylaxis for this type of surgery.

Study Overview

  • Observational study: This study will not change your standard care. We will review your medical records to check if you develop any infections within 30 days after surgery.
  • Participation: Around 2000 male patients will take part in this study from multiple countries. Your participation will help improve care for future prostate cancer patients.
  • Data collection: We might need to call you on day 30 to 40 to obtain missing information. Data from multiple hospitals will be analyzed.

Key Terms

  • Antibiotic: A drug that fights bacterial infections
  • Antibiotic prophylaxis: Giving antibiotics at the start of surgery to prevent infections
  • Minimally invasive prostate cancer surgery: Robotic-assisted or laparoscopic techniques to remove the prostate
  • Post-surgical infection: An infection that develops within 30 days after surgery
  • Infection prevention measures: Steps taken before and during surgery to reduce infection risk, such as sterilizing equipment and proper hand hygiene

Study Aims

The DEEP URO study aims to:

  • Learn how often infections happen after prostate cancer surgery using robotic or laparoscopic techniques.
  • Understand if different ways of using antibiotics before surgery lead to different results in preventing infections.
  • Gather information to help plan future, more detailed studies if needed.

Benefits and Risks

Benefits: While we cannot guarantee specific treatment benefits for you, this research may provide valuable insights that could improve the care and outcomes for future patients undergoing similar surgeries. It may also help reduce the unnecessary use of antibiotics and combat antibiotic resistance.

Risks: There are no significant risks associated with taking part in this observational study. We will ensure that your data are kept confidential and used for the purposes of this study only.

Any questions?

Contact us

For more information about the DEEP-Uro study, please contact us at contact@deepuro.eu